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KMID : 1007520080170010203
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Food Science and Biotechnology
2008 Volume.17 No. 1 p.203 ~ p.207
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Hepatoprotective Effect of Grifola frondosa Water Extract on Carbon Tetrachloride-induced Liver Injury in Rats
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Lee Jong-Suk
Kim Han-Sup
Lee Yoon-Joo
Yong Cheol-Soon
Choi Han-Gon
Han Gi-Dong
Kim Jung-Ae
Lee Jae-Sung
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Abstract
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The present study aimed at assessing the protective effect of water extract from fruit body of the Grifola frondosa (GFW) on carbon tetrachloride (CCl4)-induced hepatotoxicity. Rats orally administered with GFW 0.5, 1.0, 2.0 g/kg for 14 days were treated with CCl4 to induce hepatotoxicity. Pretreatment with GFW remarkably prevented the elevation of serum AST, ALT, ALP, LDH, γ-GTP, and liver lipid peroxides in CCl4-treated rat and GFW administration in liver injured rats by CCl4 showed significant (p<0.05) protection of liver as evidenced from normal serum enzymes and malondialdehyde (MDA) levels. In the ultrastructural changes, administration of CCl4-induced damage of hepatocytes with vacuolation, a highly damaged endoplasmic reticulum, and degenerating nuclei. However, pre-administration with GFW preserved normal ultrastructure of hepatocytes. These results suggest that GFW had an effect to inhibit CCl4-induced liver injury in rat, and that it could be used as an effective hepatoprotective agent against chemical-induced liver damage.
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KEYWORD
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Grifola frondosa, carbon tetrachloride(CCl4), hepatoprotection, ultrastructural change, aspartate aminotransferase/alanine aminotransferase, AST/ALT
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